Endocrine Abstracts

Introduction: McCune-Albright syndrome (MAS) is a rare non-inheritable genetic disease. It is attributed to an early embryonic postzygotic somatic activating mutation of GNAS, leading to a mosaic that causes polyostotic fibrous dysplasia, café au lait macules and polyendocrinopathy.Aim: To present two cases of this rare syndrome.Case report: A 38-year-old male patient presented with a bone lesion of the forehead and acromegali...

Introduction: Primary aldosteronism (PA) is the most common cause of endocrine hypertension. Its prevalence varies from 5-15%, which depends mainly on the cut-offs of the diagnostic tests.Aim: To estimate the prevalence of PA in patients with different stages of hypertension based on a dynamic overnight diagnostic test.Methods: One hundred ninety nine hypertensive patients were divided in 3 groups according to the stage of hyperten...

Introduction: Primary aldosteronism (PA) treatment is either pharmacological with aldosterone receptor antagonists (MRAs) or surgical with the resection of the responsible adenoma. The efficacy of MRAs treatment is based on the normalization of blood pressure (BP) in relation to potassium levels. However, it remains unclear whether the stimulation of renin levels during treatment could serve as an additional marker of adequate MR blockade.Aim: To investi...